Neurocutaneous melanosis presenting with intracranial amelanotic melanoma.

Neurocutaneous melanosis presented with giant congenital melanocytic nevi and primary intracranial melanoma

Neurocutaneous melanosis is a rare neurocutaneous syndrome defi ned by the presence of multiple and /or giant congenital cutaneous nevi and melanocytic deposits in the central nervous system with the infi ltration of leptomeninges. The major medical concern with giant congenital cutaneous nevi is high risk of developing cutaneous melanoma, leptomeningeal melanoma, and neurocutaneous melanosis. ...

Multifocal amelanotic conjunctival melanoma

Clinical and histopathological features of four cases of multifocal amelanotic malignant melanoma of the conjunctiva in association with 'acquired melanosis sine pigmento' are reported. The absence ofconjunctival pigmentation in this extremely rare combination of lesions prevented early diagnosis and clinical monitoring. As a result orbital exenteration was required in three cases. This multice...

An unusual case of neurocutaneous melanosis.

The neurocutaneous melanosis (NCM) is a rare, neuroectodermal dysplasia defined by the association of giant or multiple, nonmalignant pigmented cutaneous nevi with leptomeningeal melanosis or melanoma. As a rule, the cerebral pathological substratum is characterized by a melanocytic infiltration of the leptomeninges, often leading to hydrocephalus. The most frequent clinical symptomatology star...

Case Report: Primary Leptomeningeal Melanoma in a Patient with Neurocutaneous Melanosis

Neurocutaneous melanosis: Criteria for diagnosis

Sir, We read with great interest the case report by Ahuja et al of a child, 6 weeks old, with multiple giant congenital melanocytic nevi and central nervous system melanosis. Neurocutaneous melanosis has been reported to manifest itself most commonly within the first two years of life and children with this entity have been born as still births or have been reported at as early as one month of ...